Drug design methods have made significant new advances over the last ten years, mainly in the areas of molecular modelling. In more recent times important developments in theory have led to a different type of modelling becoming possible, the so‐called de novo or automated design algorithms. In this new method the programs perform much of the chemist's thinking, in finding appropriately sized chemical groups to fit into a target site. However this is a combinatoric problem which has no general analytical (...) solution; it is ripe for optimization. Other advances, such as combinatorial chemical synthesis and screening, will dramatically influence the search for new lead structures for target sites, which at present are poorly understood. Already these methods are being applied to peptide libraries. Peptides do not make good drug compounds because of their poor bioavailability; further, their flexibility reduces their affinity. In some cases peptide backbones can be removed and replaced with rigid non‐peptide scaffolds. (shrink)

ABSTRACTPresenting information in a coherent fashion has been shown to increase processing fluency, which in turn influences affective responses. The pattern of responses have been explained by two...

Oxford Studies in Philosophy of Religion is an annual volume offering a regular snapshot of state-of-the-art work in this longstanding area of philosophy that has seen an explosive growth of interest over the past half century.

Philip James Jones, a Fellow of the British Academy, was one of the most distinguished, complex, and challenging of medieval historians. His works on the Italian city-states of the thirteenth to fifteenth centuries and on Italy's agrarian history are monuments built to last, benchmarks that defined the field for a generation. Jones was elected a Fellow of the British Academy in 1984 and was awarded the Serena Medal for Italian studies in 1988. He won a major open scholarship in (...) Modern History at Wadham College, University of Oxford. Jones took a First in Modern History in 1945 and was appointed to a research studentship at Magdalen College. He had also secured a temporary teaching post at Glasgow University. All Jones's previous works flowed into the 700 pages of his mammoth book Italian City-State: from Commune to Signoria. (shrink)

Description: Since its inception, the discussion surrounding Open Theism has been dominated by polemics. On crucial philosophical issues, Openness proponents have largely been devoted to explicating the underlying framework and logical arguments supporting their perspective against competing theological and philosophical perspectives. As a result, very little constructive work has been done on the interconnections between Open Theism and the natural sciences. Given the central place of sciences in today's world, any perspective that hopes to have a broad impact must necessarily (...) address such disciplines in a sustained and constructive manner. To date such engagements from the Openness perspective have been rare. God in an Open Universe addresses this deficiency. This book demonstrates that Open Theism makes a distinctive and highly fruitful contribution to the conversation and constructive work occurring between philosophy, theology, and the sciences. The various essays explore subjects ranging from physics to prayer, from special relativity to divine providence, from metaphysics to evolution, and from space-time to God. All who work at the intersection of theology and the sciences will benefit greatly from these essays that break new ground in this important conversation. Endorsements: ""These essays present what is, in my view, the most promising development in theological thinking in our time, and they do so in a way that is both scholarly and accessible. The book is a must for anyone interested in Christian faith and in science."" -Keith Ward University of Oxford ""Open theists affirm the same openness of the future that religious believers assume when they pray and almost all humans assume when they act. The open future is intuitive; but can it be rigorously defended? God in an Open Universe shows that it can. Open theism has always been an attractive view of God; now it becomes a philosophically rigorous one as well. -Philip Clayton Claremont School of Theology About the Contributor(s): William Hasker is Profesor Emeritus of Philosophy at Huntington University. He is the author of numerous articles and five books, including The Emergent Self and The Triumph of God Over Evil. Thomas Jay Oord is Professor of Theology and Philosophy at Northwest Nazarene University. He is the author or editor of more than a dozen books, including Defining Love and Creation Made Free. Dean Zimmerman is Professor in the philosophy department at Rutgers, The State University of New Jersey. He is editor or co-editor of several books, including (with Peter van Inwagen) Persons: Human and Divine. (shrink)

Young people have an enormous stake in the present and future state of Earth. Almost half of the human population is under the age of 25. If young people’s resources of energy, time, and knowledge are misdirected towards violence, terrorism, socially-isolating technologies, and unsustainable consumption, civilization risks destabilization. Yet, there is a powerful opportunity for society if young people can participate positively in all aspects of sustainable development. In order to do so, young people need education, political support, resources, skills, (...) and hope. This volume offers a global perspective on education initiatives by and for young people that promote a transition to sustainability. It includes 38 essays co-authored by 68 contributors from 25 nations, representing a diversity of geography, gender, and generation. "The development of youth leadership has been a central concern of my professional work. Young people have a lot to offer to sustainable development and should participate in planning for our planet’s future. This rich collection of theoretical and practical approaches captures the growing response of young people to this challenge. I am particularly pleased with the attention paid to the role of often-underrepresented regions of the world, to the role of women, and to the Earth Charter in the creating of a peaceful and sustainable future." Julia Marton-Lefèvre, Director General of IUCN (International Union for Conversation of Nature), and former Rector of the University for Peace "This book is a rich, global tapestry depicting the inter-linkages among youth, education and sustainable development. What is particularly interesting is that it shows how education, at all levels, can be a powerful engine for promoting sustainability. This work is an important contribution to the United Nations Decade of Education for Sustainable Development." Goolam Mohamedbhai, Secretary-General, Association of African Universities, and Past President, International Association of Universities "This important and skillfully-prepared book comes at a critical time.... A great strength of this volume is that it blends together theoretical and practical insights regarding education for sustainable development by and for young people. It is written from diverse cultural perspectives from all world regions. Readers, from many fields, especially young people and their teachers, will find it timely and relevant. I hope that it will inspire the younger generation to get involved in seeking solutions to the challenges we face." James Gustave Speth, Former Administrator of the United Nations Development Programme, and Dean Emeritus of the School of Forestry and Environmental Studies at Yale University "It is my hope that you are inspired, as I have been, by Young People, Education, and Sustainable Development: Exploring Principles, Perspectives, and Praxis, for the stories in this volume are full of the possibilities that emerge when we honor and support young people." Ruud Lubbers, Former Prime Minister of The Netherlands, and past United Nations High Commissioner for Refugees. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 545 Haroutunian, would have balked at the notion that their " empiricism " could be abstracted from the christological and trinitarian confession 0£ the church. In general, it would seem that a genuinely " empirical" approach would seek to engage the actual truth claims of religious com· munities on their own terms-even when those claims conflict with historicist suppositions. Second, in so far as Dean thinks (...) there is a uniquely American reli· gious experience or style of thought, privileging that style seems a dangerous move indeed. Dean is not unaware of the dangers. He specifically denies that he is engaging in any form of " American exceptionalism " (p. 25) ; it is simply that an " appropriately American historicism, centering on American culture, would have a greater chance of suggesting practices that work for and are true for America " (p. 24). But I am skeptical that such disclaimers address the real problem. Near the very end of the book, Dean suggests that a modi· fied naturalism might lead to " a notion of God that was more genuinely American than anything earlier," culminating in the recognition that " American thought about God is really the thought of a national com· munity" (p. 144). Descriptively that may well be the case; but then the Christian theologian must seek norms elsewhere. History Making History does not show us how historicist insigh~ might be incorporated into ecumenical, trinitarian theology, but that does not mean the attempt will prove unfruitful. Meanwhile, this bit of philosophical tale-telling will hold the interest of readers theological and otherwise. JOSEPH L. MANCINA Yale University New Haven, Connecticut Medical Ethics: Sources of Catholic Teaching. By KEVIN D. O'ROURKE, O.P. and PHILIP BOYLE, O.P. St. Louis: Catholic Health Associa· tion, 1989. Medical Ethics: Common Ground for Understanding. By KEVIN D. O'RouRKE, O.P. and DENNIS BRODEUR. St. Louis: Catholic Health Association, 1989. Healthcare Ethics: A Theological Analysis. By KEVIN D. O'RouRKE, O.P. and BENEDICT ASHLEY, O.P. 3rd ed. St. Louis: Catholic Health Association, 1989. Sources of Catholic Teaching is a compendium of recent "official" statements by Roman Catholic ecclesiastical bodies on issues concern· ing medical ethics. Arranged alphabetically according to topics, this col- 546 BOOK REVIEWS lection of statements from the papacy, the Roman Congregations, and the conferences of Catholic bishops could prove to he a very helpful reference tool. It contains a brief introduction which seeks to explain the role of these statements in the Catholic moral theology and Catholic medical ethics, a table of contents of the statements included, and then the statements themselves. In most instances it does not contain the entire document or statement hut only excerpts therefrom. There are some weaknesses in this work. First, these statements are not self-explanatory; they are in need of interpretation and explanation in many instances. But the authors present only the bald text and do not offer any explanatory comments. They apparently presume that these statements are pellucid to the reader, hut this is an unwarranted pre· sumption. For example, clarifying comments should have been added to the statement from the Declaration on Euthanasia because the allocution of Pius XII about giving lethal doses of analgesia is not entirely clear. A second difficulty with this work is the brief and somewhat insubstantial introduction on conscience and the role these statements should play in the formation of conscience. This sort of work invites a substantial and extended commentary on the nature of moral judgments, the relationship of conscience to the natural law, and the authority of these statements. The authors note that not all of the official statements issued by various organs of the Church are of equal authority, hut they do not try to identify the specific authoritative status of the various statements they include in their work. The reader is thus left to his or her own devices to determine, for example, the relative weight of statements of the administrative hoard of the NCCB versus statements of state episcopal conferences. A still further problem is that some of the statements are of virtually no significant authority for Catholics. For example, the statement of the administrative hoard of the NCCB on AIDS is of questionable... (shrink)

A growing body of literature critical of ethics review boards has drawn attention to the processes used to determine the ethical merit of research. Citing criticism on the bureaucratic nature of ethics review processes, this literature provides a useful provocation for (re)considering how the ethics review might be enacted. Much of this criticism focuses on how ethics review boards _deliberate,_ with particular attention given to the lack of transparency and opportunities for researcher recourse that characterise ethics review processes. Centered specifically (...) on the conduct of ethics review boards convened within university settings, this paper draws on these inherent criticisms to consider the ways that ethics review boards might enact more communicative and deliberative practices. Outlining a set of principles against which ethics review boards might establish strategies for engaging with researchers and research communities, this paper draws attention to how _Deliberative communication_, _Engagement with researchers_ and the _Distribution of responsibility_ for the ethics review might be enacted in the day-to-day practice of the university human ethics review board. This paper develops these themes via a conceptual lens derived from Habermas’ (The theory of communicative action. Volume 1: Reason and the rationalization of society, 1984 ) articulation of ‘communicative action’ and Fraser’s (Social Text, 25(26), 56–80, 1990 ) consideration of ‘strong publics’ to cast consideration of the role that human ethics review boards might play in supporting university research cultures. _Deliberative communication_, _Engagement with researchers_ and the _Distribution of responsibility_ provide useful conceptual prompts for considering how ethics review boards might undertake their work. (shrink)

We present a formal system, E, which provides a faithful model of the proofs in Euclid's Elements, including the use of diagrammatic reasoning.

This collection of essays provides the first in-depth examination of camp as it relates to a wide variety of twentieth and twenty-first century music and musical performances. Located at the convergence of popular and queer musicology, the book provides new research into camp's presence, techniques, discourses, and potential meanings across a broad spectrum of musical genres, including: musical theatre, classical music, film music, opera, instrumental music, the Broadway musical, rock, pop, hip-hop, and Christmas carols. This significant contribution to the field (...) of camp studies investigates why and how music has served as an expressive and political vehicle for both the aesthetic characteristics and the receptive modes that have been associated with camp throughout twentieth and twenty-first-century culture. (shrink)

Proof-theoretic reflection principles are schemas which attempt to express the soundness of arithmetical theories within their own language, e.g., ${\mathtt{{Prov}_{\mathsf {PA}} \rightarrow \varphi }}$ can be understood to assert that any statement provable in Peano arithmetic is true. It has been repeatedly suggested that justification for such principles follows directly from acceptance of an arithmetical theory $\mathsf {T}$ or indirectly in virtue of their derivability in certain truth-theoretic extensions thereof. This paper challenges this consensus by exploring relationships between reflection principles (...) and principles of mathematical and transfinite induction as well as the status of the latter with respect to various foundational characterizations of number theory. (shrink)

Joshua Greene has argued that several lines of empirical research, including his own fMRI studies of brain activity during moral decision-making, comprise strong evidence against the legitimacy of deontology as a moral theory. This is because, Greene maintains, the empirical studies establish that “characteristically deontological” moral thinking is driven by prepotent emotional reactions which are not a sound basis for morality in the contemporary world, while “characteristically consequentialist” thinking is a more reliable moral guide because it is characterized by greater (...) cognitive command and control. In this essay, I argue that Greene does not succeed in drawing a strong statistical or causal connection between prepotent emotional reactions and deontological theory, and so does not undermine the legitimacy of deontological moral theories. The results that Greene relies on from neuroscience and social psychology do not establish his conclusion that consequentialism is superior to deontology. (shrink)

This article outlines a training activity that can enable both business and governmental professionals to translate the principles in a code of ethics to a specific list of company-related behaviors ranging from highly ethical to highly unethical. It also explores how this list can become a concrete model to follow in making ethical decisions. The article begins with a discussion as to what will improve ethical decision making in business and government. This leads us to explore the factors that can (...) most easily lead to improvement, namely a comprehensive code of conduct and employee training. From there we look at the Critical Incident Technique as a training strategy that has the potential for identifying those behaviors that distinguish really outstanding behaviors from those that go by the book, and can be used to encourage more independent thinking and to set expectations for future decisions. If employees are given the skills and examples that will enable them to make better decisions, they can apply them to any situation. (shrink)

This essay rethinks the concept of biocommunism by rearticulating it via a sensitivity towards individual suffering rather than the human species as a whole. The essay is divided into three parts. The first part outlines Marx’s concept of alienation because of the central role that the fourth kind of alienation plays in Dyer-Witheford’s original conception of biocommunism. The second part briefly elaborates on the discussion of species in the Kyoto School. These two parts lead to the third part, where a (...) novel interpretation of biocommunism is outlined, focusing on individual suffering rather than the human species. (shrink)

State and civil society -- Empire without state -- Politics of life -- Saint Foucault -- Blood-dried codes -- The state of immanence -- Virtual state-making -- When society prevails -- Political and economic theology -- Foucault's apologia of neoliberalism.

Biocommunism, while not a new concept, has yet to be the subject of considerable academic research. Wróbel has most recently taken it up. Beginning with Dyer-Witheford’s suggestion of a return to Marx’s concept of species-being, or Gattungswesen,4 this essay will elaborate on the influence of this term in the early Marx and the role which the notion of species held in the Kyoto School. The essay concludes with an allusion to Agamben and Butler that aims to provide a much-needed discussion (...) about the feasibility of the term biocommunism as an improved notion of communism more suitable for the current reality. (shrink)

Recent critics have called attention to the alienation of contemporary academics from broad currents of intellectual activity in public culture. The general complaint is that intellectuals are finding a professional home in institutions of higher learning, insulated from the concerns and interests of a wider reading audience. The demands of professional expertise do not encourage academics to work as public intellectuals or to take up social, literary, or political matters in imaginative and perspicuous ways. More problematic is the relative absence (...) of religion in the writings of those who aspire to work as public intellectuals. This essay reviews recent attempts by William Dean, Cornel West, Jean Bethke Elshtain, Stephen Carter, and Robin Lovin to remedy the problem of academic alienation and to address the place of religion in American life. (shrink)

The Knowability Paradox purports to show that the controversial but not patently absurd hypothesis that all truths are knowable entails the implausible conclusion that all truths are known. The notoriety of this argument owes to the negative light it appears to cast on the view that there can be no verification-transcendent truths. We argue that it is overly simplistic to formalize the views of contemporary verificationists like Dummett, Prawitz or Martin-Löf using the sort of propositional modal operators which are employed (...) in the original derivation of the Paradox. Instead we propose that the central tenet of verificationism is most accurately formulated as follows: if φ is true, then there exists a proof of φ Building on the work of Artemov (Bull Symb Log 7(1): 1-36, 2001), a system of explicit modal logic with proof quantifiers is introduced to reason about such statements. When the original reasoning of the Paradox is developed in this setting, we reach not a contradiction, but rather the conclusion that there must exist non-constructed proofs. This outcome is evaluated relative to the controversy between Dummett and Prawitz about proof existence and bivalence. (shrink)

This article details day-to-day ethics issues facing MBAs who occupy entry-level and mid-level management positions and offers defined examples of the stressors these managers face. The study includes lower-level managers, essentially excluded from extant literature, and focuses on workplace behaviors both undertaken and observed. Results indicate that pressures from internal organization sources, and ambiguity in letter versus spirit of rules, account for over a third of the most frequent unethical situations encountered, and that most managers did not expect to face (...) those issues. Various contextual factors accounted for 32% of the organizational factors that affected decisions. We discuss implications for the workplace, especially the unique ethics challenges for newer managers. (shrink)

Computationalism holds that our grasp of notions like ‘computable function’ can be used to account for our putative ability to refer to the standard model of arithmetic. Tennenbaum's Theorem has been repeatedly invoked in service of this claim. I will argue that not only do the relevant class of arguments fail, but that the result itself is most naturally understood as having the opposite of a reference-fixing effect — i.e., rather than securing the determinacy of number-theoretic reference, Tennenbaum's Theorem points (...) towards a sense in which portions of our computational vocabulary should be regarded as model-relative. (shrink)

The authors examine the nature of the relationship between social science and philosophy and address the sort of work social science should do, and the role and sorts of claims that an accompanying philosophy should engage in. In particular, the authors reintroduce the question of ontology, an area long overlooked by philosophers of social science, and present a cricital engagement with the work of Roy Bhaskar. The book argues against the excesses of philosophising and commits itself to a philosophical approach (...) more deeply grounded in the social sciences. (shrink)

This paper contends that eating shapes the self; that is, our practices and understandings of eating can cultivate, reinforce, or diminish important aspects of the self, including agency, values, capacities, affects, and self-understandings. I argue that these self-shaping effects should be included in our ethical analyses and evaluations of eating. I make a case for this claim through an analysis and critique of the hypothesis that young women’s vegetarianism is a risk, sign, or “cover” for eating disorders or disordered eating. (...) After outlining the relevant empirical literature, I suggest that the evidence for this hypothesis is inconclusive. Given this uncertainty, we should consider the risks of making a mistake when accepting or rejecting this understanding of young women’s eating. I argue that these risks importantly include negative effects on the self, such as damage to moral and epistemic agency. Along with other potential consequences of mistakenly accepting the hypothesis, these effects give us reason to reject it pending more conclusive research. Overall, this paper offers a philosophical intervention into the debate over the relationship between vegetarianism and eating disorders while illustrating the ethical importance and relevance of eating as a self-shaping activity. (shrink)

This article details day-to-day ethics issues facing MBAs who occupy entry-level and mid-level management positions and offers defined examples of the stressors these managers face. The study includes lower-level managers, essentially excluded from extant literature, and focuses on workplace behaviors both undertaken and observed. Results indicate that pressures from internal organization sources, and ambiguity in letter versus spirit of rules, account for over a third of the most frequent unethical situations encountered, and that most managers did not expect to face (...) those issues. Various contextual factors accounted for 32% of the organizational factors that affected decisions. We discuss implications for the workplace, especially the unique ethics challenges for newer managers. (shrink)

This article approaches social media from the theory of the religio-political practice of acclamation revived by Agamben and following twentieth-century social and political thought and theology (of Weber, Peterson, Schmitt, Kantorowicz). It supplements that theory by more recent political-theoretical, historical and sociological investigations and regards acclamation as a ‘social institution’ following Mauss. Acclamation is a practice that forms publics, whether as the direct presence of the ‘people’, mass-mediated ‘public opinion’, or a ‘public mood’ decipherable through countless social media postings. The (...) article surveys issues of differential geographies of access, weighting of posts, value-creation, orality and gesture, algorithmic governmentality, and Big Data and knowledge production. It argues that social media constitute a public from a mass of individualized, private postings. It concludes that they make possible forms of political calculability and action, yet are continuous with ritual and liturgical elements of political life. This study contributes to an analytics of publicity. (shrink)

One formulation of the Categorical Imperative tells us to treat humanity as an end in itself. It has become common to think that ‘humanity’ (die Menschheit) here refers to some minimal power of rationality that is necessarily possessed by any rational agent, but I argue that this common reading is misguided. Instead, ‘humanity’ refers to a good will, the will of a being who is committed to moral principles. This good will reading of ‘humanity’ is not only suggested by passages (...) in which Kant specifically discusses humanity, but also is more consistent with the main ideas of Kant's ethics. (shrink)

This chapter contains sections titled: What Should We Treat as an End in Itself? Value and Ends The Argument for the Humanity Formulation How Particular Duties Follow Final Thoughts Bibliography.

While this ‘extraordinary’ book appears as an intermezzo within the Homo Sacer series, it supports two fundamental theses with its own philological, epigraphic, liturgical and religious-historical research, and a close reading of figures such as Ernst Kantorowicz and Marcel Mauss. These theses concern political power first as an articulation of sovereign reign and economic government and, secondly, as constituted by acclamations and glorification. These can be approached theoretically through its author’s engagement with Michel Foucault’s genealogy of governmentality and with the (...) Erik Peterson/Carl Schmitt debate on the closure of political theology. Agamben’s reformulation of power and his derivation of liberal governmentality from the theological oikonomia prove convincing. A renewed analytics of power and politics of resistance should be possible, however, without recourse to a project seeking to deactivate all profane powers including those of public bureaucracies. (shrink)

Kant emphasizes that moral philosophy must be divided into two parts, a metaphysics of morals, and an empirical application to individuals, which Kant calls 'moral anthropology'. But Kant gives humanity (die Menschheit) a prominent role even in the purely rational part of ethics – for example, one formulation of the categorical imperative is a demand to treat humanity as an end in itself. This paper argues that the only concepts of humanity suited to play such a role are the rational (...) idea of humanity, and the rational ideal derived from this idea, which Kant discusses in Critique of Practical Reason and other texts. (shrink)

We analyze the pointwise convergence of a sequence of computable elements of L1 in terms of algorithmic randomness. We consider two ways of expressing the dominated convergence theorem and show that, over the base theory RCA0, each is equivalent to the assertion that every Gδ subset of Cantor space with positive measure has an element. This last statement is, in turn, equivalent to weak weak Königʼs lemma relativized to the Turing jump of any set. It is also equivalent to the (...) conjunction of the statement asserting the existence of a 2-random relative to any given set and the principle of Σ2 collection. (shrink)

It was proposed that ethical evaluation of insurance claim padding behavior would be affected by characteristics of the policyholder, insurance agent, and company. These three factors were manipulated in written scenarios and the premise was tested in a factorial experimental design. No significant support was found for an effect of any of the three factors on ethical perceptions of claim padding. However, females found claims padding to be significantly less ethical than males. Given a claim scenario where the actual loss (...) was $500 and the claimed amount was $3000, subjects awarded an average of $986.91 on the claim. Many respondents were willing to compensate victims for intangible losses as well as tangible losses. (shrink)

Mark Freeman's inspiring account of the burgeoning field of the psychological humanities presents a clear and compelling vision of what the discipline of psychology might become. Engaging and accessible, this bold, provocative book is destined to spark significant discussion and debate in audiences including advanced undergraduates, postgraduates, and professionals in the field of psychology with interests in theoretical and philosophical psychology.

Respect is one of the central concepts in contemporary moral thought. It plays a prominent role in everyday, pre-philosophical moral thinking, as well as in recent moral theory and applied ethics. Yet basic questions about the concept and role of respect have received less attention than might be expected. This volume takes up some of these basic questions. The book is not meant to be a comprehensive handbook that covers all aspects of the topic of respect, nor is the focus (...) of the book mainly historical. Rather, the aim is to give leading experts in the field a chance to present their latest ideas and point the research on respect in new directions. Following an introductory historical essay, Part I addresses questions of what respect is, its nature and basis. Part II examines questions in moral theory, for example what exactly ought to be respected, what role respect plays in morality, and which different types of respect are appropriate and morally significant. Part III deals with the practical application of requirements of respect. The essays in this volume will be of interest both to scholars and students working on issues of respect and to anyone interested in this central moral notion. (shrink)